Best Protein Structure Quotes

"The intense pressure found in the deep ocean can affect the structure of proteins in fish cells, distorting the protein shape. The chemical trimethylene oxide counters this effect, ensuring that proteins retain their original configurations."

"Alphafold predicts the structures of proteins based on data pertaining to other proteins."

"Fundamentally, it's a physical problem, so the optimal protein structure has to be an energetic minimum."

"The sequence of amino acids in a gene determines the primary structure of the protein."

"This is not random in any way. This is a stable, particular structure that it obtains. And in this particular protein, there's this big cavity here and it is just the right size and shape, kind of lock and key like, to bind to some substrate molecule."

"Make as many contacts as possible, and then you actually end up getting a structure that looks more like a protein."

"If you know the structure of a protein, you can learn a lot about its function in vivo."

"Primary structure is just the sequence, secondary structure now we have shapes, tertiary structure is three-dimensional."

"Knowing that a protein has at least one transmembrane helix is very useful in terms of predicting its function."

"What you're seeing here in green is the crystal structure of the protein TlpB."

"Amino acids joined by peptide bonds is how we create that polypeptide or protein."

"A protein is a big chain of amino acids."

"If the protein undergoes structural changes, it will be very visible in HSQC."

"The unique sequence of amino acids determines the protein's 3D structure which will determine how it functions."

"A functional protein consists of one or more polypeptides precisely twisted, folded, and coiled into a unique shape."

"The primary structure of a protein is the unique sequence of amino acids."

"Tertiary structure is when the protein coils and folds, producing a three-dimensional shape."

"We can really get atomic structures of many proteins quite rapidly."

"These amino acids help stabilize protein structure through the hydrophobic effect."

"AlphaFold achieved a median accuracy of 92.4 GDT."

"Normal hemoglobin, which is hemoglobin A in adults, is made up of two alpha chains and two beta chains."

"There's often a unique way for that sequence to form itself."

"The protein folding problem seeks to understand how the sequence of amino acids enables the production of the 3D structure of a protein."

"The shape of a protein determines its function; if we change its shape or its conformation, we change the ability for it to function."

"Every bend, every twist, every coil on that protein gives it a specific shape and a specific function."

"A change in the amino acid sequence means that there is a change in the primary and therefore tertiary structure, possibly affecting protein structure and function."

"It's always been the dream of computational biology to be able to go from the sequence of a gene to the structure of the corresponding protein."

"Alpha Fold has got a couple of different quality criteria associated with the structure."

"Protein shape is determined by amino acid sequence."

"The structure of a protein determines what its function is."

"The quaternary protein structure is the overall structure of the protein."

"The structure of the protein is integral to its function as an enzyme."

"The specific shape of a protein influences the specific function of that protein."

"The specificity of an enzyme is due to the complementary shape of its active site and the substrate."

"The primary structure of a protein is essential for all the other structures of a protein."

"Once these long chains fold upon themselves and have a particular biological function, they're considered proteins."

"This restriction has an effect on protein structure."

"The alpha helix is in a very, very stable region of the Ramachandran plot."

"It is absolutely incredible the abilities that are built into the structure of this protein."

"The design of drugs is happening increasingly as a result of the molecular knowledge of the structure of the proteins that they're targeting."

"Tertiary structure is the overall 3D arrangement of the protein."

"When we talk about tertiary structure, we're talking about the overall 3D arrangement of a particular protein."

"The protein density shines much brighter because it's coherently the same from image to image; the protein is rigid, whereas the micelle is disordered."

"Ab initio reconstruction is so important for new proteins or any kind of project where you don't already know the structure of the protein you're trying to solve."

"That's actually the active state of the protein and the cloud is the blurred-out substrate which is another unfoldase molecule that's being unraveled."

"If there is a mutation in any of these triplet codes, that can result in your amino acid being coded for differently, in other words, it can result in a different amino acid and change the shape of the protein."

"The primary structure of a protein is simply the sequence of amino acids."

"Allosteric regulation and cooperativity specifically, is the whole idea that the binding at one subunit of a multi-subunit protein can have an effect at the other subunits."

"The shape that the protein folds into is what allows it to do its job."

"With this lecture, for the first time, you can start to see why considerations of protein structure are really important as regards your body."

"The peptide bond is the bond that joins amino acids together in proteins."

"The structure of a protein absolutely dictates what the protein does and how the protein functions."

"Very very small changes in the structure of a protein have enormous changes on the action of that protein."