"The evidence of taxonomic relationships is overwhelming when you look at the comparisons between genomic DNA sequences."
"Genomics... it's the most significant evolutionary milestone we've made in the last 14 billion years."
"One of the reasons why I love talking about this is if you take all these different areas, healthcare and genomics is the one that is guaranteed to affect you at some point."
"Sequencing is the platform upon which everything sits."
"Ultimately sequencing improves diagnostics therapeutics drug discovery."
"The genomic revolution is going to transform healthcare completely."
"We believe that the opportunities are in the stocks in our genomic revolution fund which is all about the future."
"Humanity was close to understanding the human genome and turned its attention to the potential of human cloning."
"BioNano Genomics is a play on data and healthcare at the same time."
"BNGO is a very good play to have in your portfolio especially if you're underweight on healthcare and you're underweight on genomics."
"We can combine the genome with multiple modality testing."
"One of the great interesting areas is genomics and CRISPR and things like that and that's the thing you need to dive in personally."
"The Human Genome Project was trying to read all of these nucleotide based pairs to understand how genes are set up."
"So the first human genome was three billion dollars to sequence in today's money right now you can get a medical grade whole genome sequence like you could for 200."
"What's more informative than a million genomes? A billion genomes."
"What's been remarkable about genomics in the 11 and a half years or so since the end of the genome project... all the different ways that genomics has now found its way as a scientific discipline into areas of incredible importance."
"The future is actually here, genomic medicine is continuing to grow but we're already doing this in the clinic and we're already beginning to see some of the dramatic impact that this can have on patients."
"You cannot be a specialist anymore. If you're a genomicist, you have to be a specialist in every single disorder."
"Despite being able to sequence the entire human genome, we only understand a fraction of that genome and what it does."
"Could we actually do this for DNA? Could we monitor continuously and ubiquitously for genomics?"
"Genomics can add such a new dimension of understanding to medicine as we know it today."
"We're not winning that war yet, but what we've done with genomics, we are started understanding how cancer thinks."
"We are able now to sequence the DNA of each and every one of us within an hour or two."
"Our genomes encode a variety of functional molecules, predominantly proteins and RNA species, that interact together to mediate biochemical processes and create biological structures."
"Even 20 years ago, genome sequencing, the ability to read the DNA using nanobiosensors were simply nonexistent."
"Personal genomes are now a very low cost; it's like insurance you should get it whether you are gonna need it or not."
"Genome mining has really revolutionized the field of microbial natural products research."
"We've entered this entirely new era of genomics where we look at genes or proteomics where we look at proteins and now lipidomics where we look at the lipids inside of cells."
"The fields of genomics, proteomics, and now lipidomics will allow us to have many more answers."
"It's up to you guys to develop the next generation of convolutional filters that actually apply to genomics and single cell data."
"This is our idea of transfer learning in this setting."
"We look at intramodule connectivity so how connected is the gene to all other genes within this module."
"The sequencing cost has decreased dramatically... from about hundred million dollars per genome to nowadays it's actually probably below $1,000 per genome."
"Next-generation sequencing studies have tremendously advanced our understanding of the genes."
"...she helped create methods and automation pipelines that were critical for sequencing the human genome."
"...orchestrates the Genome Institute's efforts to explore next-generation and third-generation sequencing technologies..."
"...sequence six human genome equivalents in about a 10- or 11-day period."
"This is a great platform for targeted validation where you're looking for single nucleotide changes."
"The error rate for substitutions is extraordinarily low."
"The error rate has been improving pretty dramatically over time."
"Let's spend just the last five or 10 minutes here talking about some applications of next-gen sequencing."
"We first published the initial description of the whole genome tumor normal comparison in 2008."
"Most recently, we've moved forward, exploiting the digital nature of the technology."
"For well-annotated genomes like the human genome, researchers may choose to base their RNA-seq analysis on the existing annotation and reference available."
"I chose Hisat because it provides moderate to high sensitivity and at the same time it has better runtimes and requires less memory."
"GPS is the name of this algorithm... it locates proteins on the genome."
"Volcano plots are useful for identifying genes that are significantly regulated."
"There's increasing evidence to suggest that cost savings is available for patients, insurance companies, and the health care system through exome sequencing."
"The cost for sequencing the human genome has been reduced nearly a million fold over since the Human Genome Project's first sequencing of the human genome."
"Technologies for sequencing DNA in that last 13 years have completely changed the face of genomics."
"Generating a human genome sequence today is almost trivial."
"You need to know how it went from the raw sequence all the way to VCFs."
"So if you have reference genomes, that's great. It's getting better."
"Whole genome is really the most comprehensive type of experiment and it will give you the most information."
"But I think genomics is going to be one of the, the absolute, most important advances."
"Genomics really is revolutionizing the more recent hominin fossil record."
"If you knew the sequence of the human genome, you'd be able to identify similar genes by sequence homology."
"The highest resolution map you can have for a genome is the sequence."
"It studies sets of genes and looks to see whether they are enriched in your experimental dataset when compared to your control dataset."
"Sequencing the genome these days is actually becoming cheaper and cheaper."
"This is work not only by the DNA Learning Center but also by the genomics education Alliance."
"When you do deep sequencing looking for off targets... it's actually remarkably accurate."
"A whole Human Genome in a day—that's what these technologies have enabled."
"It took me a year to sequence a seven and a half KB genome; nowadays, you could do it in 20 minutes."
"Millions of SARS-CoV-2 genomes have been sequenced and deposited in databases."
"It took 10 years to do the first human genome; today, you could do it in a day for a thousand dollars."
"The cost per human genome has declined by several orders of magnitude."
"The more we learn about comparative genomics, the more these relationships will be precisely defined."
"...if you find a new virus, you sequence its genome and you immediately classify it by computational biology methods."
"Trace Genomics is a company with a mission to extend genetic monitoring to a farmer's soil."
"We can sequence our own genome, we can sequence the microorganisms in and around us."
"The entire genome was duplicated... this duplication of information may very well have been associated with... a lot of morphological complexity."
"The grand goal of the Beyond the Human Genome Project is to provide crucial assets to support a medical delivery transition from a focus on treatment of diagnosed illness to a focus on wellness and prevention."
"Genomics has ignited the digital biology revolution with the cost of sequencing outpacing Moore's Law."
"There's a study published in BMC Genomics in 2018 that really just catapulted fasting research into a whole different world altogether."
"This is really the new age of functional genomics for understanding gene function, for recreating disease models, and creating new transgenic animals."
"Genomic codes are really going to be a real point of practice, education, and research."
"Next-generation sequencing is a technology that captures DNA sequences and generates digital data."
"Genomics is a study of the total or part of the genetic or epigenetic sequence information of organisms and attempts to understand the structure and the function of these sequences."
"The genomic revolution... turned the detailed analysis of the genomic data from a dream to a hypothesis and then suddenly it became a current reality."
"We're going to be talking about computational biology, specifically genomes, networks, evolution, and health."
"Whole genome shotgun surveys all the bacteria, virus, and fungi etc. in your sample, it reveals functional pathway enrichment and novel chemistry."
"Some of these differences might not mean anything; they might be benign. Others of these differences might be pathogenic and might contribute to your disease."
"If you have a region of the genome where you have many, many variants that align, then you can have more confidence that a variant that's called in that region would actually be real."
"Bioinformatics is using data science techniques to understand things such as RNA and RNA transcription, understanding the genome."
"Single cell RNA sequencing has the potential to revolutionize biology because it allows you to compare gene expression patterns both across different cell types and also within different cell types."
"The important thing is to understand the application like transcriptomics, how to analyze transcriptomic data, genomics, how to analyze genomic data."
"This roadmap of the intricate genetic codes across the human body empowers doctors to better diagnose and treat disease."
"So what does one do? Well, one sequences genomes, right?"
"It's never been easier, cheaper, or faster to sequence a genome."
"We are at the beginning of an era of genome surveillance for outbreak identification."
"Sequencing projects have read the genomes of a wide range of organisms like humans and this provides opportunities to screen DNA to identify potential medical problems."
"With a single experiment we'll be able to identify where all these different factors are binding to the genome from one set of data."
"The patterns we see in genomic changes are typical for a primate or mammalian genome."
"DNA sequencing got about a million times cheaper and that's really what enables the stuff we can do now."
"The human genome sequence allowed us to then go and look for biological activity."
"The non-coding genome is riddled with RNA."
"Maybe the genome does have that and a lot of the ones we don't see function for could be just storage for an appropriate time that we haven't detected yet."
"We sequence a person's cancer which we can now do quite easily."
"Whole genome sequencing is not prohibitively expensive anymore."
"This is the model we think how to use genomics in precision medicine."
"The elegance of it all is that you need to know is the nature of the genome, one of those seven types."
"Welcome back to the course on functional genomics."
"Human genomics needs to engage in implementation science focused on real-world health care settings."
"The Illumina HiSeq gives you about 3 billion pairs on the base pair reads, so about 600 gigabases."
"The goal for the term is for all of you guys to actually feel comfortable taking on the task of interpreting the human genome and understanding the molecular basis of human disease."
"The genome, the change, the control regions, the words within these regions, the factors, the regulators that control and bind these regions, the dynamics, the networks that interconnect, and the grammars within these regions."
"The general idea of pathway and network analysis is to help gain some kind of mechanistic insight into your genomics data."
"Enrichment analysis... has been used in tens of thousands of papers, pretty much everybody who runs genomics kind of runs this type of pathway analysis by default."
"The thousand genomes project is a large source of our population data."
"The genome is all of the genes in a cell, whereas the proteome are all the proteins that a cell can make."
"Next Generation sequencing literally is A's, C's, T's, and G's in a text box."
"This is really illustrates how clean Next Generation sequencing data can be."
"The value of having two different genomic views of the same cancer."
"The cost of sequencing has gone down... today we now have a thousand-dollar genome."
"Having a thousand dollar human genome has led to a lot of data in biology being generated."
"It produces spliced alignments for RNA-seq for eukaryotic genome assemblies."
"Welcome to the Om Genomics show, and this is the long requested video on project ideas."
"In the last few years, new technologies have made it easier and easier to produce large amounts of sequence data from biological materials."
"Visualize your own genomic data and create your own annotations."
"...this is the first demonstration ever in history of genomics, whole tumor genomics, predictive proteomics, targeted proteomics driving what we call a molecular driven clinical decision at the protein level."
"LIMA is basically a software that will retrieve the differentially expressed genes."
"Whole genome sequencing is very prominent and in this workshop we'll understand how to do that kind of analysis."
"The Cancer Genome Atlas published the molecular profile of endometrial cancer, identifying four different subtypes."
"The field of genomics offers new therapies to attack cancer, heart disease, and other chronic illnesses that afflict billions."
"Genomics is a brand new biology that deals with structure, function, and mapping of genomes."
"We've created the largest integrated system in genomic analysis."
"You can get almost the same results with 4x coverage as you do with 30x."
"Gene set enrichment is... to detect a general trend without setting the limit and where to cut off of differential genes."
"Annotation of the whole genome is the determination of gene location and gene function in the genome."
"The human genome sequencing project... saw the need to create some sort of an entity that would take advantage of the power of genomics for improving biomedicine."
"One of the key challenges in human genomics research is to characterize the immense array of genomic and phenotypic diversity across ethnically diverse human populations."
"The real goal of understanding viral genomes is to manipulate them so we can understand how viruses work."
"We sit on the tip of an evolutionary spectrum and can leverage evolutionary genomics to find better drug targets."
"Knowledge of the genome leads to knowledge of proteins, which leads to knowledge of potential receptors."
"Personalized medicine... says knowledge of your genome genetic profile will lead to a personalized medicine."
"Exome sequencing has become very popular; it's probably the most popular form of genome sequencing right now."
"When you're doing de novo genomes... the paired end is exceptionally valuable in trying to build these overlap maps of how the fragments stitch together to form a whole genome."
"The sequencing gets cheaper and better, the bottleneck is the bioinformatics."
"Next Generation genome sequencing is a technique that you can use to analyze the entire human genome."
"The human genome project... is just the beginning."
"We are very much at an inflection point in the genomics industry as a whole."
"Genomics is entering the clinic and will impact people's lives more broadly."
"Genomics is an incredibly powerful tool... it's the most profound thing that I've ever seen in my life."
"With that much power, there are lots of questions that we will have to address about what it means to be human."
"You can do a genome today in a day and it costs you $1,500."
"Now it's about 1 thousand dollars per human genome."
"If we could look at a genome and understand how these networks are encoded, we could predict biologically relevant interactions directly from the genome."