"Cytosol is an amazing tool that can be used for drug discovery, medical discovery, and more."
"Drug companies are doing this strategy all the time. Between 2005 and 2015, almost 80% of new patents were for existing drugs."
"It would be nice to be able to make the first all small molecule catalytic drug that's capable of seeking and destroying these rogue disease-causing proteins."
"Development of longevity drugs is one of the hottest areas in biotechnology."
"An example of de novo drug development is epoprostenol. This story was the culmination of 50 years of basic science research."
"Using graph neural networks to develop drug repositioning for Covid-19."
"Drug development is a slow, expensive, long process, but it's so valuable."
"It's so valuable because we're at long last learning enough about the circuit afflicted in schizophrenia that we can start to have rational drug development."
"Nowadays, we can think about a different kind of pharmacology which is the development of a degrader."
"We need to change our emphasis from always trying to develop the next billion-dollar drug and instead trying to spend more time understanding exactly what is going on mechanistically in the body and in the brain."
"These attributes can really affect the stability, the bioavailability, and the manufacturability of our drug products."
"So even a drug right now in phase 3 trial, you know, all the patients have to be enrolled."
"Any time is really a good time during your drug development program to communicate with the FDA."
"I will develop the oral gavage administration method and to do so I have to develop an oral formulation for these compounds."
"If it proves successful, then we will see the first marine microbial natural product to become a useful drug."
"Well actually, I work in cancer research and a drug Design Lab, and I'm about to finish undergraduate studies."
"This is really the golden age of disease research, translational medicine, and drug discovery."
"Every drug approved by the FDA was in some way based on biomedical research funded by the NIH."
"If one of our goals is to look for novel drug or therapeutic targets, by taking a pathway approach, we can think about not necessarily targeting the most well-known gene."
"Just potency is not sufficient for a molecule to become a drug."
"If you have a docked molecule with the best docking score and all the properties are fine according to the computational methods, can we take them into in vitro and in vivo analysis? Yes, if you are confident enough."
"I think there will be a very strong case that these drugs are acting by slowing the aging process."
"It was stunning that a drug could start as late as that and still have a full lifespan benefit."
"We now have insight into these novel pathways in its biology so that we can create drugs against these new targets."
"If we could uncover the mechanisms that contribute to the transition between the first picture and the second picture, then we maybe will have a drug that can reverse that process."
"Clinical pharmacology is a translational discipline essential for drug development and therapeutics in humans."
"We seek to be included in the drug development process from the very beginning."
"If you could revolutionize the drug discovery process, make it ten times faster, more efficient, and more likely to pass through the clinical trials because you can predict the properties better, that has to also be of enormous commercial value."
"The endocannabinoid-like compounds... may certainly bring new drugs to a wide variety of diseases."
"Excited by the possibility the mRNA will rapidly fill critical gaps not met by traditional small molecule drugs, available biologic treatments, and emerging gene therapies."
"The value of the patient's voice in the context of patient-focused drug development, especially in the setting of rare and fatal diseases with significant unmet medical needs."
"The drug I've been working on for the past five years just got approved by the FDA."
"A lead is a molecule that's very likely to be further developed to be a drug candidate."
"And right now, there are no drugs to treat that, neither to treat the underlying protein issues nor the immune cell dysfunction."
"We can essentially develop aptamers to develop powerful oligonucleotide drugs that can be used to treat many different diseases."
"The classic question is why we don't have many aptamers in the clinic, despite all these great properties for therapeutic drugs."
"I hope that we can bring this drug to market very quickly."
"We aim to develop more innovative drug delivery vehicle concepts that are efficient and safe for clinical use."
"It's incredibly exciting when you see a company making a drug using technologies that was developed in a little fume hood at the back end of a lab in Princeton."
"The urgency to apply AI to reduce the 10 years and 2 billion dollars to get a drug to market is imperative across the industry."
"We're very excited about the potential for these types of molecules to be developed into antiviral drugs."
"Generative AI could help to find ways to create new drugs and also the efficacy of those drugs, how good those drugs are."
"The path to drug development is full of forks in the road."
"It's not just a joking thing; it does many efforts to be taken, it may take some years, two decades to find the drug, and it's costly."
"We passed a milestone where we can now make drugs based on this knowledge and potentially slow down aging itself."
"The best thing for our health is to get the very best drug science we can possibly develop."
"I got interested in how we got from plants to modern drugs."
"In silico predictive modeling accelerates and economizes early-stage drug discovery."
"It is tempting to think that using some computational tools we can represent these compounds, associate their chemical structures with their special properties, and perhaps develop models whereby we can develop new drugs."
"Many of our current drugs are derived from these plant metabolites."
"The discovery of a new drug from scratch is a very lengthy, resource-intensive process."
"QSAR is a screening mechanism that lets us make some early decisions about which compounds might have potential or show promise as a drug candidate."